"I thought it was really sweet of her and characteristic of her to think about her family on her big day. "Zan had given us gifts and really sweet letters to open … the moment she was getting married," Zan's sister, Summer Rigby, said. "It was just the two of us out on the little patio, their little covered porch," Zan said.Īlthough their families weren't there in the flesh, Zan made sure they were there in spirit. The intimate event perfectly suited the low-key couple. Neither she nor Mac is comfortable with much attention. "I was really excited about them," Zan said, "and when I turned around he had the ring."Ī lot of brides are eager to be the center of attention. "She was supposed to look and be, like, 'Oh, headphones'… but she got really excited and started jumping up and down and hooting and hollering about the headphones," Mac said. When the couple got home from celebrating their second anniversary on May 13, Mac surprised Zan with a special anniversary present: a pair of dollar store headphones. The Lugoff, S.C., residents have been together ever since. At that moment, the town bells started ringing and Zan, taking it as a sign, leaned in for that first, sweet kiss. Mac wanted a kiss Zan wanted to make him wait. By the end of the night, they were staring into each other's hearts in downtown Camden, S.C. Mac made up for the delay with Southern charm and a handsome smile. "He said he was nervous and had to get some courage." "He showed up right before I wanted to leave," Zan, a lab tech, said. A French / American citizen born in Paris in 1965, he is a 27 year veteran with AFP starting out at the photo desk in Paris in 1989 before upping sticks. But she was still waiting when clock approached midnight. "My mom's very protective, so it took him a couple of tries going by her office," Zan, 31, said.Īfter talking on the phone, Zan invited Mac to go out with her and some friends to see a band. "I somehow finagled her mother … into giving her my number," Mac said. In 2011, Mac first glimpsed a photo of Zan Owens on her mother's desk in the manufacturing plant where he works. To score a date with the woman of his dreams, Mac Norris had to convince her mother he was a worthy suitor.
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In the UK, biannual ultrasound is recommended, following European Association for the Study of the Liver guidelines (see Table 1 ). While recommendations regarding inclusion of AFP as part of HCC surveillance varies between guidelines, there is consensus among all professional bodies that ultrasound is required for HCC surveillance . Results from several studies have showed that HCC surveillance is cost-effective, although there is ongoing debate as to whether this is consistent across all aetiologies of CLD . Research involving cohort studies and mathematical modelling conclude that HCC surveillance results in earlier diagnosis, receipt of curative treatments and improved survival . In HCC, potential benefits of early detection are that curative therapies, such as resection or transplantation, could be offered sooner, resulting in improved survival rates .īiannual ultrasound and alpha-fetoprotein (AFP) measurement are the diagnostic tests used for surveillance they are widely available, affordable and have evidence supporting their utility. Around 90% of HCC cases have a background of cirrhosis or chronic liver disease, identifying individuals with these conditions as target ‘at risk’ populations for receipt of a surveillance test. Owing to poor prognosis and low surveillance uptake, HCC presents unique challenges to the NHS because half of UK cases are considered preventable . Other, rarer aetiologies include alpha 1 antitrypsin disorder, haemochromatosis and primary biliary cholangitis . Increasing age, male sex and smoking are also independent risk factors for HCC . The incidence of NASH is rising as metabolic syndrome becomes a common phenomenon and 20% of HCC cases have NASH as the attributable factor in the UK and United States . In the UK and United States, alcohol-related liver cirrhosis and non-alcoholic steatohepatitis (NASH) are significant causative factors for HCC. However, the attributable risk of HCV has decreased since the advent of antiviral medication, which results in sustained virological response (undetectable viral load six months after completion of treatment) . Hepatitis C virus (HCV) remains the most common aetiology of HCC in Western Europe, North America and Japan . HBV is the main causative factor of HCC in East Asia, which has the highest HCC incidence in the world. Hepatitis B virus (HBV) is directly oncogenic and is the most significant risk factor for developing HCC - it is responsible for 50% of HCC cases . Globally, viral hepatitis remains the most common cause of HCC . The epidemiology of HCC varies by region. This article will outline the importance of surveillance and how HCC is diagnosed, and will provide an overview of the current available treatment options, including the involvement of pharmacy teams where appropriate. Considering the rise in cases and the potential burden of the condition for patients, it is important that pharmacists are aware of the signs of HCC and know how to appropriately refer. Prognosis remains poor, with five-year survival rates less than 20% this is unchanged in the past decade despite advances in therapeutics . The average age at diagnosis is 69 years and the majority of cases occur in men . The incidence of HCC is rising: new cases have increased by 160% over the past three decades in the UK alone, with around 17 new cases diagnosed per day . It is the sixth most common cancer worldwide, with 905,700 new cases in 2020, and is the fourth most common cause of cancer-related death, responsible for 830,200 deaths each year . Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is a growing global health concern. Understand the main treatment options for HCC and which patients are eligible for curative treatment.Identify the risk factors for developing hepatocellular cancer (HCC) and understand which patients require surveillance.Journal of Pharmaceutical Health Services ResearchĪfter reading this article, you should be able to:.International Journal of Pharmacy Practice.Antimicrobial resistance and stewardship. To learn more about how stem cell therapy can help resolve your shoulder pain, schedule an appointment at Suncoast Orthopaedic Surgery & Sports Medicine today. In cases of osteoarthritis, stem cell therapy can even decrease or stop the rate of deterioration of the shoulder joint! Over time, the stem cells will help heal the damaged tissue to reduce inflammation and ease the pain. The stem cell treatment involves harvesting the bodys reserve of stem cells from the back of the hip area, and re-injecting them into the rotator cuff injury. So, when stem cells are injected near injured tissue in the shoulder, they can replace the damaged cells. Stem cells are capable of developing into different types of cells with specialized functions. Stem cell therapy can help relieve shoulder pain by stimulating and supporting the regeneration of the damaged tissue. How Stem Cell Therapy Can Help with Shoulder Pain With shoulder tendinitis, the tendons in the shoulder become inflamed, leading to pain and stiffness in the shoulder. Shoulder tendinitis develops as a result of overuse of the tendons in the shoulder. Most common in older age, osteoarthritis can cause pain and stiffness in the affected joint, such as the shoulder. Osteoarthritis occurs from wear and tear on the cartilage of a joint. Shoulder bursitis causes pain, stiffness, and swelling in the shoulder joint. Overuse of a joint, such as the shoulder, can cause inflammation in the bursae, leading to a condition called bursitis. Bursitisīursae are fluid-filled sacs that reduce friction between tissues in the body’s joints. This injury is common in people who perform repetitive shoulder motions. When a tear occurs in the rotator cuff, pain and weakness in the shoulder result. Regenerative medicine treatments, such as platelet-rich plasma (PRP) therapy and stem cell therapy, may be effective in treating shoulder pain by promoting the body’s natural healing processes and repairing damaged tissues in the shoulder joint. The rotator cuff is a band of muscles and tendons that circle the shoulder joint to provide stability. Common Causes of Shoulder Pain: Torn Rotator Cuff Stem cell therapy, in particular, helps many patients overcome shoulder pain without having to undergo invasive surgery.Ĭontinue reading to learn more about the most common causes of shoulder pain and how stem cell therapy can help. While shoulder pain can be debilitating, there are treatments available to help you fully recover. The shoulder is subject to all types of injuries, from a torn rotator cuff to bursitis to osteoarthritis and more. So, when shoulder injuries occur, people often have trouble carrying out their regular routines. These cells are injected directly into the rotator cuff where they work with the bodys natural healing process in repairing the tear. The shoulder plays a crucial role in your ability to perform many everyday tasks, from reaching a high shelf to carrying objects. Later traditions turned him into a Christian convert, but as Sabine Baring-Gould observed: "The name of Longinus was not known to the Greeks previous to the patriarch Germanus, in 715. An early tradition, found in a sixth or seventh century pseudepigraphal "Letter of Herod to Pilate", claims that Longinus suffered for having pierced Jesus, and that he was condemned to a cave where every night a lion came and mauled him until dawn, after which his body healed back to normal, in a pattern that would repeat till the end of time. No name for this soldier is given in the canonical Gospels the name Longinus is instead found in the Acts of Pilate, a text appended to the apocryphal Gospel of Nicodemus. Longinus' legend grew over the years to the point that he was said to have converted to Christianity after the Crucifixion, and he is traditionally venerated as a saint in the Roman Catholic Church, Eastern Orthodox Church, and several other Christian communions. This person, unnamed in the Gospels, is further identified in some versions of the legend as the centurion present at the Crucifixion, who said that Jesus was the son of God, so he is considered as the first Christian. This act is said to have created the last of the Five Holy Wounds of Christ. The lance is called in Christianity the "Holy Lance" (lancea) and the story is related in the Gospel of John during the Crucifixion. His name first appeared in the apocryphal Gospel of Nicodemus. Longinus is the name given to the unnamed Roman soldier who pierced the side of Jesus with a lance and who in medieval and some modern Christian traditions is described as a convert to Christianity. Since the Gospels are silent on the name of the Roman soldier who pieced Jesus’ side, tradition and pius legends have come down to us that his name of Longinus. John actually say about the situation.īut one of the soldiers with a spear opened his side, and immediately there came out blood and water. Traditionally the name of the Roman soldier that pierced Christ’s side was Longinus. Is Longinus the name of the roman centurion who pierced Jesus?Īccording to tradition the answer is yes. The tool is available on multiple platforms and is free software. In addition to increasing volume of MP3 files, it also works for boosting M4A volume, enhancing WAV volume, and even increasing MP4 video volume. MP3Gain is an audio normalization software tool. Then, click the RUN button and all your MP3 files will be converted and the volume will be boosted in a flash. I had no need for an entire complicated suite I just wanted to do this one thing. I have amassed a collection since the 90’s and some have really high volume and some have really low volume. I was hunting for a program to make sure all my MP3’s were the same volume. Start to Make MP3 LouderĪfter completing all the above operations, you can choose the output path by clicking the inverted triangle icon at the bottom. MP3Gain analyzes and adjusts MP3 files so that they have the same volume. You can also customize the amount of increase in gain. Simply load the files, hit the analyze button, run the gain correction, and then transfer the files to an mp3 player. With no loss in quality, the volume of the mp3s increased. On the pop-up window, you will see a volume icon adjust the slider to the right to boost the volume. MP3Gain did exactly what we needed it to do. With no loss in quality, the volume of the mp3's increased. Choose MP3 as the Output Format and Increase the MP3 Volumeįirst, click the Output Format window on the right and select MP3 under the Audio category, then click the Parameter settings button below the profile. MP3Gain did exactly what we needed it to do. Or you can directly drag and drop all the MP3 files to the main interface. Then, click the Add Files button to batch import all your desired MP3 files to it. To increase MP3 volume, launch the program and open Converter. Launch the MP3 Volume Booster and Add the MP3 Files designs within were inspired by classical elements high paneled back and arms Fireplaces Became a focal point, the mantel was the most decorative feature in the room box like structure (similar to Gothic chairs) High backed chair- early renaissance Rectilinear and box-like legs in the back are closer together than the front legs, and are joined by a perimeter stretcher allowed guests to pivot from left to right to allow for conversation ornamentation emphasized carved techniques Caquetoire Chair A conversation chair, translated to chatter. Most chairs this time were small enough to be arranges in the room according to need and function French furniture during the early French Renaissance designed on a smaller scale and was more lightweight than the heavier Gothic style that preceded it. Rooms have few furnishings, even in wealthy homes, and room use is flexible. Decoration concentrates on floors, walls, and ceilings. Large chimneypieces serve as focal points. Doors, stairways and windows are important architectural features. interiors continue to feature Gothic and classical elements with classical becoming dominant In terms of interiors and Fontainebleau, who creates the first French Renaissance interiors? Rosso Fiorentino and Francesco Primaticcio create the first French Renaissance interiors at Fontainebleau What are some of the design characteristics of the Fontainebleau - slender nymphs with clinging drapery, garlands, scrolls, strapwork, grotesques, and stucco figures. Balustrade A parapet or railing composed of a handrail, balusters, and a base. Quoin The cornerstone on the angles of a building marks the corner by its difference in rustication, color, size, or material from the wall. Pilaster A vertical member with the general form and proportions of a column, but rectangular in section. Interior details include round arches, deep cornices, large stone chimneypieces, elaborate balustrades, and coffered and beamed ceilings. built by/for Francis the 1st The keep The keep houses guard chambers, public spaces, private apartments, etc. Hunting lodge built outside of Paris - barely occupied Furnishings were very minimal but ornate. The castle-like plan features a walled enclosure with four corner towers surrounding an open courtyard that contains the keep Roofs feature balustrades, lanterns, chimneys, and dormers with classical columns and pilasters. Large rectangular and arched windows flanked by pilasters symmetrically over the lower facade. What are some design characteristics of Château de Chambord? - Inspired by italian renaissance models, the design emphasizes grand scale, symmetry, classical ordering, and the monarchies symbolic value. Often have fortified rectangular compounds with a central courtyard and corner turrets within it, the main building has a greek cross and introduces the apartment, chambre and cabinet. Describe in detail the layout of a typical French Renaissance Châteaux. What are the preferred building materials? Stone is the most preferred building material followed by brick. Salon an elegant apartment or living space. Antechamber first room of a suite typically used for eating and waiting Chamber Cabinet A small, private room within a suite used for conducting business. rooms arranged in a linear sequence and progress from most public to most private spaces. Apartment a series of rooms associated with a single person On May 13, 2008, Microsoft released Office 2008 Service Pack 1 as a free update. There is no such problem in Word 2004 or X. This issue has not been fixed in the SP2 (version 12.2.0, released in July 2009). If a structure is recopied from a Word 2008 document, and is pasted back into ChemDraw, it appears as a non-editable image rather than a recognized chemical structure. Word 2008 does not retain the structural information when a chemical structure is copied from ChemDraw and pasted into a document. Some features are missing on Excel 2008 for Mac, including: data filters (Data Bars, Top 10, Color-based, Icon-based), structured references, Excel tables, Table styles, a sort feature allowing more than three columns at once and more than one filter on a sort.īenchmarks suggest that the original release of Office 2008 runs slower on Macs with PowerPC processors, and does not provide a significant speed bump for Macs with Intel processors.Ī data-compatibility problem has also been noted with CambridgeSoft's chemical structure drawing program, ChemDraw. Microsoft's response is that adding VBA support in Xcode would have resulted in an additional two years added to the development cycle of Office 2008. Other unsupported features include: OMML equations generated in Word 2007 for Windows, Office "Ribbon", Mini Toolbar, Live Preview, and an extensive list of features are unsupported such as equivalent SharePoint integration with the Windows version. The lack of Visual Basic for Applications (VBA) support in Excel makes it impossible to use macros programmed in VBA. Office 2008 for Mac lacks feature parity with the Windows version. In May 2008, Microsoft announced that VBA will be making a return in the next version of Microsoft Office for Mac. AppleScript and the Open Scripting Architecture will still be supported. Microsoft Visual Basic for Applications is not supported in this version. As a result, such Excel add-ins dependent on VBA, such as Solver, have not been bundled in the current release. In June 2008, Microsoft announced that it is exploring the idea of bringing some of the functionality of Solver back to Excel. In late August 2008, Microsoft announced that a new Solver for Excel 2008 was available as a free download from Frontline Systems, original developers of the Excel Solver.> However, Excel 2008 also lacks other functionality, such as Pivot Chart functionality, which has long been a feature in the Windows version. On FebruGeoff Price revealed that the format conversion update for Office 2004 would be delayed until June 2008 in order to provide the first update to Office 2008. Office 2008 supports the new Office Open XML format, and defaults to saving all files in this format. Mac-only features included are a publishing layout view, which offers functionality similar to Microsoft Publisher for Windows, a "Ledger Sheet mode" in Excel to ease financial tasks, and a "My Day" application offering a quick way to view the day's events. Office 2008 for Mac includes the same core programs currently included with Office 2004 for Mac: Entourage, Excel, PowerPoint, and Word. Unlike Office 2007 for Windows, Office 2008 was not offered as a public beta before its scheduled release date. Office 2008 is the only version of Office for Mac supplied as a Universal Binary. Office 2008 was originally slated for release in the second half of 2007 however, it was delayed until January 2008, purportedly to allow time to fix lingering bugs. ** “The skill, knowledge and depth of MyEarTraining is absolutely outstanding.” - Educational App Store Andreas Kissenbeck (University of performing Arts Munich) It’s designed for musicians who want to improve their relative pitch recognition abilities and get one step further towards perfect pitch. This app app works by combining different ear training approaches like isolated sounds, singing exercises, and functional exercises (sounds in tonal context) to train your ears, thus maximizing results. Interval songs and practice piano are also included. For major music topics, this app offers different courses and lessons including basic music theory. Input answers using buttons or virtual piano keyboard. You can use tonal exercises with solfeggio or singing exercises to improve your inner ear. Advanced users can progress through seventh chord inversions, complex chord progressions and exotic scale modes. Users with no ear training experience begin with simple perfect intervals, major vs. Whether you are new to music theory, need to prepare for an intensive school exam, or are an experienced musician, there are over 100 aural exercises to help you push your music skills. You can practically train your ears while waiting at the bus stand, traveling, or even at your coffee desk. This app makes ear training practice possible almost anywhere and anytime on the go, thus saving you from the hassle of assembling musical instruments. The benefits of mastering ear training include improved intonation and musical memory, confidence in improvisation or the ability to transcribe music more easily. It practices the ability to connect music theory elements (intervals, chords, scales) with real sounds you hear. Ear training is highly essential for any musician - be it a composer, singer, songwriter or instrumentalist. Install MyEarTraining - Ear Trainer on your Mac using the same steps for Windows OS above.ĭiscovering the right Education app for your needs is hard, which is why we are happy to give you MyEarTraining - Ear Trainer from myrApps. Once MyEarTraining is downloaded inside the emulator, locate/click the "All apps" icon to access a page containing all your installed applications including MyEarTraining.The search will reveal the MyEarTraining - Ear Trainer app icon.Open the Emulator app you installed » goto its search bar and search "MyEarTraining".On your computer, goto the Downloads folder » click to install Bluestacks.exe or Nox.exe » Accept the License Agreements » Follow the on-screen prompts to complete installation. Install the emulator on your PC or Mac:.Download Bluestacks Pc or Mac software Here >. We recommend Bluestacks because you can easily find solutions online if you run into problems while using it. Download an Android emulator for PC and Mac:. There’s a stealth sequence in the game that feels a bit hamfisted, too, with each assassination triggering an animation that usually just felt like it lacked the *OOMPH* I expected. I only died a handful of times in my first playthrough but almost all of those were to failed wall jumps. The wall-running doesn’t really feel like it engages properly every time. I do have a few problems with how Bright Memory plays, however. Movement is snappy and the gunplay feels good. There’s also a grappling hook that lets you maneuver wide expanses. On top of your standard movement and jumping, she can also slide, double jump, and wall-run. Shelia has a handful of movement options, too. It provides a sense of personal growth over the short campaign and genuinely helps you feel like you’re getting more powerful. As you play through the story (which can be finished in less than two hours), you’ll come across relics that can be spent on this upgrade tree. Speaking of upgrades, Bright Memory: Infinite features an upgradeable skill tree that will let you unlock and upgrade abilities for your sword, firearms, and more. It’s fast, it hits hard, and upgrading it will let you take out foes from distance. In my opinion, the real star of the show is Shelia’s sword. Shelia can use psychokinesis to pull enemies to her as well. You’ll get a handful of guns as you play, each with a powerful alternate firing mode. The game plays like your average first-person shooter with a few extra mechanics mixed in. It does make for an enjoyable ride though. A scientist-adjacent hero must stop a military group from acquiring ancient power that would almost certainly be used for evil. There are some goofy, fun setpiece moments in the game but as strange as it feels to say, this story has been done before. The story is enough to keep driving the action forward, but it will not win any awards. On top of that, intel suggests a top general for the SAI, a military organization, is making his way to the same location to acquire an ancient power. The SRO super agent arrives to discover a black hole has emerged in the sky and is causing problems. On a night full of celebration, Shelia is called to suit in and get straight to the mission. Language/Crude Humor: There are a few instances of foul language used in Bright Memory: Infinite including D*** and B****. Sexual Content: There is no explicit sexual content in Bright Memory: Infinite, though it did feel like the game wanted to suggest Shelia was alluring at times.ĭrugs and Alcohol: There are no drugs or alcohol. Violence: The game features blood and gore ranging from gunshot wounds to body parts being severed by blades. Spiritual Content: There are what appear to be deified humans and demons. Now that I’ve had hands-on time with it, I’m happy to say Bright Memory: Infinite is a fun, albeit quick, gaming experience despite its flaws. Second, they clearly didn’t have a large budget for voice talent. One look at a trailer for Bright Memory: Infinite will tell you two things. Q2 – I am unable to gain access to router admin settings page. Click Continue and your password will be recovered.Click Continue and in the next page answer two of the security questions you have previously set.You will be now on Router Password Recovery page where you require to enter the router’s Serial Number which you will find at the back of your router.When prompted Authentication Required dialog box click “Cancel”.However if you have changed the default settings and have previously set “Password Recovery” feature on then – Q1 – How to use the router password recovery feature?īy default your username is admin and password is password. Troubleshoot common router admin page errors You will now be logged in into your NETGEAR Router Configuration Panel/.(Both username and password are case-sensitive.) The default username is “admin” and the default password is “password”. Type in the user name and password in the given fields.Launch your default Web Browser that you use to access the Internet.Once that is done, follow these steps to access NETGEAR Router Admin Page. Logging into NETGEAR wireless router admin page is an easy process and before you continue, make sure that you are connected to the NETGEAR Router’s network. Update its firmware or troubleshoot of your router – all of this can be done. It is the configuration panel for your router and you can access it any time using your web browser to make the required changes for your router. NETGEAR Router Login – – sign in to access admin panel, setup new wireless connection, change default WiFi password settings. |